Blade finds himself alone surrounded by enemies, fighting an up hill battle with the vampire nation and now humans. He joins forces with a group of vampire hunters whom call themselves the Nightstalkers. The vampire nation awakens the king of vampires Dracula from his slumber with intentions of using his primitive blood to become day-walkers. On the other side is Blade and his team manifesting a virus that could wipe out the vampire race once and for all. In the end the two sides will collide and only one will come out victorious, a battle between the ultimate vampire whom never knew defeat, facing off against the greatest vampire slayer.
Wesley Snipes, Kris Kristofferson, Dominic Purcell, Jessica Biel, Ryan Reynolds, Parker Posey, Mark Berry, John Michael Higgins, Callum Keith Rennie, Paul Levesque, Paul Anthony, Françoise Yip, Michael Rawlins, James Remar, Natasha Lyonne